SAFETY AND EFFICACY OF SUBLINGUAL MISOPROSTOL AND INTRACERVICAL DINOPROSTONE GEL AS CERVICAL RIPENING AGENT IN TERM PRELABOUR RUPTURE OF MEMBRANES: A COMPARATIVE STUDY

Authors

Monica R Assistant Professor Department of obstetrics and gynaecology Rajah Mirasudhar hospital Thanjavur medical college , Thanjavur
Dharini M Assistant Professor Department of obstetrics and gynaecology Rajah Mirasudhar hospital Thanjavur medical college , Thanjavur

misoprostol, dinoprostone, premature rupture of membranes

Introduction: "premature rupture of membranes" (PROM) refers to the chorioamnionitis membranes

spontaneously rupturing before the start of labour. This study compares the safety and effectiveness of

intracervical dinoprostone gel and sublingual misoprostol for cervical ripening in term PROM. Methods:

This is an analytical cross-sectional study including 100 term mothers with spontaneous PROM

attending obstetric casualty at the Department of Obstetrics and Gynaecology, Government Raja

Mirasudhar Hospital, Thanjavur, India, selected using a multistage sampling technique from the study

period of February 2021 – November 2021 (10 months). One hundred samples were assigned randomly

into two groups which were 50 in each group as group A (Misoprostol group) and group B (Dinoprostone

gel group). Results: In group A, the study participants' median ages were 25 years (8.48) and 26.2

years (6.42), respectively. The difference in age averages between groups A and B was found to be

6.03, with a statistically significant p-value of 0.016. In both groups, the induction delivery interval was

nearly equal. The link between the Indication for Lower Segmental Caesarean Section and both groups

was statistically significant. When the two groups' delivery modes were compared, natural labour was

shown to be statistically significant (p = 0.048). Normal and abnormal heart rates were statistically

significant for the association between fetal heart rate and the groups, respectively, with chi-square

values of 6.854 and 9.281 (p = 0.022 and 0.013, respectively). The remaining groups were not

statistically significant. Conclusion: It was concluded that though sublingual misoprostol is more

efficacious than intracervical dinoprostone, its safety margin is significantly less; hence, misoprostol

induction should be done only in a double setup under medical supervision.

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